We are looking for enthusiastic, self-motivated individuals who thrive in a fast-paced challenging start-up research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare, and have the fortitude to work hard, we invite you to contact us concerning a position.
Leo Wang, MD, Ph. D.
Leo David Wang, M.D., Ph.D., has joined City of Hope as an Assistant Professor with a primary faculty appointment in the Department of Immuno-Oncology and a secondary faculty appointment in the Department of Pediatrics. Dr. Wang joins City of Hope from Boston Children’s Hospital and the Dana-Farber Cancer Institute, where he was an Instructor in Pediatrics and attending physician in the pediatric hematology/oncology/hematopoietic stem cell transplantation program.
Dr. Wang earned his undergraduate degree in Molecular Biophysics and Biochemistry from Yale University, followed by his Ph.D. and medical doctorate at the University of Chicago. He successfully completed an internship and residency in pediatrics at the Children’s Hospital of Philadelphia. Dr. Wang then completed his Pediatric Hematology/Oncology/Stem Cell Transplantation fellowship at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and pursued postdoctoral research in the laboratory of Dr. Amy Wagers at the Joslin Diabetes Center and Harvard Stem Cell Institute.
Board certified in pediatrics and pediatric hematology/oncology, Dr. Wang is the recipient of multiple honors and awards. He attends on the pediatric oncology and stem cell transplant service, and is the clinical lead on Dr. Behnam Badie’s CAR T cell trial for pediatric brain tumor patients.
Research in the lab focuses on utilizing novel mass spectrometry-based phosphoproteomic techniques to identify targetable activation pathways in small numbers of rare cells. We use this unique platform to understand benign and malignant hematopoietic stem cell function, as well as to investigate critical pathways important in the immune response to cancer.
Senior Administrative Assistant
Martha brings extensive expertise navigating the complex administrative systems at City of Hope. Although her critical contributions to the Wang lab are too numerous to list exhaustively, some of her responsibilities include managing laboratory finances, coordinating laboratory logistical support, onboarding new members, organizing and coordinating schedules, event planning, and “making things happen.” Ms. Gomez-Knight often serves as the first point of contact for the lab, and any inquiries can be directed to her at MGomez-Knight@coh.org.
Martha is dedicated to service outside of her career as well, and volunteers with her church parish to help those who are less fortunate.
Nathan Hendricks obtained his Bachelor’s of Science in Chemistry in 2011 at University of California, San Diego while participating in undergraduate research and working in the UCSD Molecular Mass Spectrometry core Facility. He completed a PhD in Chemistry at University of California, Riverside with Professor Ryan Julian as his adviser. Nathan has focused on the development and application of new techniques in mass spectrometry for the analysis of biological systems. His dissertation was on the development of Action-Excitation Energy Transfer in mass spectrometry for the study of biomolecular structure.
Nathan aims to apply his experience in analytical chemistry to further our knowledge of hematopoietic stem cells, their proteome, and how changes in protein regulation and post-translational modification relate to cancer and disease. This includes developing instrumentation and methodology to detect and quantify very low-abundance proteins of importance.
Silke Lindner began her Biology studies at the Technical University in Darmstadt before she relocated to Freiburg im Breisgau, Germany to complete her PhD in the field of apoptosis at the Albert-Ludwigs-University. The research conducted in the laboratories of Dr. Ulrich Maurer and Prof. Christoph Borner focused on the impact of cell death signaling and survival in cancer as well as the immune system. She followed up with her research in the “Developmental Immunology” groups of Prof. Andreas Villunger and Dr. Sebastian Herzog at the Medical University Innsbruck, Austria. The main focus of Silke’s work was to decipher the role of the non-coding RNAs, microRNAs, in haematopoiesis and in detail early B cell development as well as in cancer development.
Besides deepening her knowledge in the tumor immunology field, she is eager to acquire technical expertise in cross-discipline techniques and extend her scientific profile towards benign and malignant hematopoietic stem cells.
Meilu McDermot dual majored in chemistry and astronomy at Williams College in Massachusetts, obtaining her Bachelors of Arts in 2016. She additionally studied computer science while earning her undergraduate degree. She focused this background on characterizing the mass and age of planetary nebulae in the Andromeda Galaxy. She has also applied her database skills to retrospective analyses of breast cancer biopsies specimens relative to initial tumor size to inform technique for diagnostic tissue sampling.
She is excited to join Leo Wang’s lab, directing her focus on characterizing peptide sequences to better characterize signaling pathways in benign and malignant pediatric hematopoietic disorders.
Sr. Research Associate
Christopher Meeks received his Bachelor’s of Science degree in 2003 and spent 5 years in industry as part of a high-throughput molecular biology pipeline. From 2003 to 2009 Chris sub-cloned and sequenced thousands of genes and promoters in support of intellectual property for augmented seed products. In 2009 Chris joined the fledgling Rodgers Laboratory at the University of Southern California. Over the course of 8 years, Chris developed an industrially paced academic laboratory and contributed to developing therapies within the renin-angiotensin system for a number of pathologies, including diabetes, wound healing, radiation injury, and Duchenne’s Muscular Dystrophy.
Chris comes to the Leo Wang lab at the City of Hope with more than a dozen years of diverse research and development experience. In addition to extensive experience with hematopoietic stem cells and bone marrow transplantation, Christopher is excited to help develop a laboratory in line with the Values at City of Hope.
Shilpa Shahani MD
Shilpa Ajit Shahani, MD, joined City of Hope as a Pediatric Instructor with primary faculty appointment in the Department of Pediatrics. Previously, she was an attending physician in the pediatric oncology and hematopoietic stem cell transplantation program at Children’s Hospital of Los Angeles.
Dr. Shahani earned a Bachelors of Science in Biomedical Engineering and a concentration in Electrical Engineering and Computer Science from Johns Hopkins University. She completed both her medical doctorate and pediatric residency at the University of Nevada, School of Medicine. Subsequently, she completed her fellowship in Pediatric Hematology-Oncology at Children’s Hospital Los Angeles and is board certified in both pediatrics and pediatric hematology-oncology. Under the mentorship of Shahab Asgharzadeh, her fellowship research focused on patterns of immune checkpoint expression on neuroblastomas and their tumor associated macrophages.
Shilpa was attracted to City of Hope’s mission of combining clinical excellence with medical advancement and is excited to develop her experience in pediatric immuno-oncology in Leo Wang’s lab. She aims to understand the interactions between the tumor microenvironment, tumor cells, and immunotherapeutics, such as Chimeric Antigen Receptor T cells and immune checkpoint inhibitors.
If you have any interest in collaborating with or joining our team, please contact us! We would love to hear from you!